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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 56 min

IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells

mer, 20/09/2017 - 02:00
Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors N...

Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

lun, 18/09/2017 - 02:00
Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway...

Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

ven, 15/09/2017 - 02:00
Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR...

Cardiovascular risk in patients with alpha-1-antitrypsin deficiency

ven, 15/09/2017 - 02:00
Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients w...

Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis

ven, 08/09/2017 - 02:00
Regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in idiopathic pulmonary fibrosis (IPF) is unclear. This study was designed to explore the role of T...

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

ven, 08/09/2017 - 02:00
Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at dete...

Intersectin-1s deficiency in pulmonary pathogenesis

mer, 06/09/2017 - 02:00
Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have demonstrated that deficiency of ITSN-1s is a cruci...

WNT signaling – lung cancer is no exception

mar, 05/09/2017 - 02:00
Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the va...

Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome

sam, 02/09/2017 - 02:00
Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical i...

RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

sam, 02/09/2017 - 02:00
Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS)...

Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients

mar, 29/08/2017 - 02:00
Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...

Expiratory central airway collapse in stable COPD and during exacerbations

ven, 25/08/2017 - 02:00
Tracheal obstruction resulting from expiratory tracheal deformation has been associated with respiratory symptoms and severe airway exacerbations. In chronic obstructive pulmonary disease (COPD), acute exacerb...

Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

mer, 23/08/2017 - 02:00
COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors.

Utility of autoimmune serology testing in the assessment of uncharacterized interstitial lung disease: a large retrospective cohort review

mer, 23/08/2017 - 02:00
Autoimmune serologies are often obtained in the initial evaluation of uncharacterized interstitial lung disease (ILD). Whether this practice is helpful in delineating connective-tissue disease related ILD (CTD...

Effect of smoking and comorbidities on survival in idiopathic pulmonary fibrosis

mar, 22/08/2017 - 02:00
Cigarette smoking has been associated with the risk of idiopathic pulmonary fibrosis (IPF). Certain comorbidities have been associated with reduced survival although some studies have indicated that current sm...

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

mar, 22/08/2017 - 02:00
Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction.

24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD

ven, 18/08/2017 - 02:00
Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover stu...

Regulation of human airway smooth muscle cell migration and relevance to asthma

mer, 16/08/2017 - 02:00
Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the ...

MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression

mar, 15/08/2017 - 02:00
Chronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that th...