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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 39 min

Bronchial thermoplasty increases airway volume measured by functional respiratory imaging

mar, 16/07/2019 - 02:00
The purpose of this study was to use CT scanning with computational fluid dynamics to evaluate the mechanisms by which Bronchial Thermoplasty (BT) improves asthmatic symptoms.

Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD

mar, 16/07/2019 - 02:00
Chronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship betwe...

Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury

mar, 16/07/2019 - 02:00
Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung i...

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

lun, 15/07/2019 - 02:00
Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study ...

Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS)

lun, 15/07/2019 - 02:00
Quantitative computed tomographic (QCT) imaging-based metrics enable to quantify smoking induced disease alterations and to identify imaging-based clusters for current smokers. We aimed to derive clinically me...

Multi-level immune response network in mild-moderate Chronic Obstructive Pulmonary Disease (COPD)

ven, 12/07/2019 - 02:00
Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells relate within and between these two biological co...

Consequences of chronic kidney disease in chronic obstructive pulmonary disease

ven, 12/07/2019 - 02:00
The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function o...

Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells

ven, 12/07/2019 - 02:00
Human rhinovirus (HRV) infections are the primary cause of the common cold and are a major trigger for exacerbations of lower airway diseases, such as asthma and chronic obstructive pulmonary diseases. Althoug...

Dose variability of supplemental oxygen therapy with open patient interfaces based on in vitro measurements using a physiologically realistic upper airway model

ven, 12/07/2019 - 02:00
Supplemental oxygen therapy is widely used in hospitals and in the home for chronic care. However, there are several fundamental problems with the application of this therapy such that patients are often expos...

Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort

ven, 12/07/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying ...

Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains

mer, 10/07/2019 - 02:00
Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and...

Do blood eosinophils strictly reflect airway inflammation in COPD? Comparison with asthmatic patients

mer, 10/07/2019 - 02:00
Airway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; howe...

Chronic obstructive pulmonary disease in rheumatoid arthritis: a systematic review and meta-analysis

mar, 09/07/2019 - 02:00
The risk and prevalence of chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis (RA) is still obscure. The current study was aimed to systematically review and meta-analyse the risk ratio (RR) ...

COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population

lun, 08/07/2019 - 02:00
Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate t...

Feasibility of low dose chest CT for virtual bronchoscopy navigation in a porcine model

lun, 08/07/2019 - 02:00
Virtual bronchoscopy navigation (VBN) is widely used for assistance in the histological examination of lung nodules. However, little is known about the optimal CT radiation dose for VBN. Therefore, we performe...

Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective

lun, 08/07/2019 - 02:00
There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1...

Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease – a prospective, randomized, multicentre cross-over trial

ven, 05/07/2019 - 02:00
Bronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenc...

Ambient air pollution and respiratory mortality in Xi’an, China: a time-series analysis

ven, 05/07/2019 - 02:00
Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The s...

Pleural thickening on screening chest X-rays: a single institutional study

ven, 05/07/2019 - 02:00
Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized. Our investigation of 28,727 chest X-rays obtained from annual health...