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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 16 min

Health status deterioration in subjects with mild to moderate airflow obstruction, a six years observational study

sam, 18/05/2019 - 02:00
Patients with COPD need to cope with a disabling disease, which leads to health status impairment.

Diagnostic accuracy of capnovolumetry for the identification of airway obstruction – results of a diagnostic study in ambulatory care

mer, 15/05/2019 - 02:00
One of the known weaknesses of spirometry is its dependence on patients’ cooperation, which can only partially be alleviated by educational efforts. Therefore, procedures less dependent on cooperation might be...

Role of TRPC1 channels in pressure-mediated activation of airway remodeling

mer, 15/05/2019 - 02:00
Bronchoconstriction and cough, a characteristic of the asthmatic response, leads to development of compressive stresses in the airway wall. We hypothesized that progressively pathological high mechanical stres...

Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study

mar, 14/05/2019 - 02:00
The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Init...

Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia

ven, 10/05/2019 - 02:00
While additional oxygen supply is often required for the survival of very premature infants in intensive care, this also brings an increasing risk of progressive lung diseases and poor long-term lung outcomes....

Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis

jeu, 09/05/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechani...

Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD

mer, 08/05/2019 - 02:00
Platelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between p...

Effect of tiotropium inhaler use on mortality in patients with tuberculous destroyed lung: based on linkage between hospital and nationwide health insurance claims data in South Korea

lun, 06/05/2019 - 02:00
Although bronchodilator inhaler therapy can improve lung function in patients with tuberculous destroyed lung (TDL), its effect on mortality has not been studied. We evaluated the effect of tiotropium inhaler ...

The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

lun, 06/05/2019 - 02:00
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction ca...

Oral corticosteroid dose changes and impact on peripheral blood eosinophil counts in patients with severe eosinophilic asthma: a post hoc analysis

ven, 03/05/2019 - 02:00
An inverse relationship between oral corticosteroid (OCS) dose and peripheral blood eosinophil (PBE) count is widely recognized in patients with severe eosinophilic asthma; however, there are limited data avai...

Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study

jeu, 02/05/2019 - 02:00
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Antibiotics are losing their effectiveness due to the emerging infectious diseases, the scarcity of novel antibiotics...

Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea

mar, 30/04/2019 - 02:00
Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap...

Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

jeu, 25/04/2019 - 02:00
C-X-C chemokine receptor type 4 (CXCR4) may be involved in the development of pulmonary arterial hypertension (PAH). CXCR4 inhibitor AMD3100 was described to have a positive effect on the prevention of pulmona...

The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis

mer, 24/04/2019 - 02:00
In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance. High-resolution computed tomography (HRCT) of the lung c...

Associations of airway tree to lung volume ratio on computed tomography with lung function and symptoms in chronic obstructive pulmonary disease

jeu, 18/04/2019 - 02:00
Decreased airway lumen size and increased lung volume are major structural changes in chronic obstructive pulmonary disease (COPD). However, even though the outer wall of the airways is connected with lung par...

Amelioration of PM2.5-induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E

mar, 16/04/2019 - 02:00
Exposure to fine particulate matter (PM2.5) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM2.5-induced toxicity may provide ...

Estimation of early life endogenous surfactant pool and CPAP failure in preterm neonates with RDS

mar, 16/04/2019 - 02:00
It is not known if the endogenous surfactant pool available early in life is associated with the RDS clinical course in preterm neonates treated with CPAP. We aim to clarify the clinical factors affecting surf...

Progenitor cell mobilisation and recruitment in pulmonary arteries in chronic obstructive pulmonary disease

mar, 16/04/2019 - 02:00
Pulmonary vascular abnormalities are a characteristic feature of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most important risk factor for COPD. It is believed that its constant exp...

Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial

jeu, 11/04/2019 - 02:00
N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients.