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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 24 min

Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

lun, 21/05/2018 - 02:00
The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP...

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

lun, 21/05/2018 - 02:00
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, including gefitinib, are first-line drugs against advanced non-small cell lung cancer with activating EGFR mutations. However, the developmen...

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

lun, 14/05/2018 - 02:00
Little is known about health risks associated with electronic cigarette (EC) use although EC are rising in popularity and have been advocated as a means to quit smoking cigarettes.

The aging lung: tissue telomere shortening in health and disease

ven, 11/05/2018 - 02:00
Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently,...

Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline

ven, 11/05/2018 - 02:00
Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking o...

Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis

jeu, 10/05/2018 - 02:00
Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affe...

Effects and molecular mechanisms of intrauterine infection/inflammation on lung development

jeu, 10/05/2018 - 02:00
Intrauterine infection/inflammation plays an important role in the development of lung injury and bronchopulmonary dysplasia (BPD) in preterm infants, While a multifactorial genesis is likely, mechanisms invol...

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

jeu, 10/05/2018 - 02:00
Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of huma...

Modelling the asthma phenotype: impact of cigarette smoke exposure

jeu, 10/05/2018 - 02:00
Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especi...

Association between oncogenic status and risk of venous thromboembolism in patients with non-small cell lung cancer

mer, 09/05/2018 - 02:00
Preclinical data suggest that oncogene (EGFR and KRAS) events regulate tumor procoagulant activity. However, few studies have prospectively investigated the clinical relevance between the presence of EGFR or K...

Cost-effectiveness of lung volume reduction coil treatment in patients with severe emphysema: results from the 2-year follow-up crossover REVOLENS study (REVOLENS-2 study)

mer, 09/05/2018 - 02:00
The REVOLENS study compared lung volume reduction coil treatment to usual care in patients with severe emphysema at 1 year, resulting in improved quality-adjusted life-year (QALY) and higher costs. Durability ...

Immunohistological features related to functional impairment in lymphangioleiomyomatosis

mar, 08/05/2018 - 02:00
Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm characterized by the pulmonary infiltration of smooth muscle-like cells (LAM cells) and cystic destruction. Patients usually present with airway obstructi...

Trends in mortality from pneumonia in the Europe union: a temporal analysis of the European detailed mortality database between 2001 and 2014

ven, 04/05/2018 - 02:00
Pneumonia is responsible for approximately 230,000 deaths in Europe, annually. Comprehensive and comparable reports on pneumonia mortality trends across the European Union (EU) are lacking.

A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia

ven, 04/05/2018 - 02:00
Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease a...

Pollution and respiratory disease: can diet or supplements help? A review

mer, 02/05/2018 - 02:00
Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world’s largest environmental health risk factor. There has be...

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

mer, 02/05/2018 - 02:00
Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implic...

Correction to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

lun, 30/04/2018 - 02:00
In the original publication [1] is an error in table 1. The correct version can be found in this Erratum:

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

ven, 27/04/2018 - 02:00
To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK.

Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects

ven, 27/04/2018 - 02:00
In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify...

Associations between comorbidities, their treatment and survival in patients with interstitial lung diseases – a claims data analysis

mer, 25/04/2018 - 02:00
Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with variou...