Facebook page







Respiratory research feeds

Subscribe to flux Respiratory research feeds
Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 28 min

G908R NOD2 variant in a family with sarcoidosis

mar, 20/03/2018 - 01:00
Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis

mar, 20/03/2018 - 01:00
Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in bo...

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

ven, 16/03/2018 - 01:00
Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the...

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance

sam, 10/03/2018 - 01:00
Smoking is a leading cause of respiratory infections worldwide. Tobacco particulate matter disrupts iron homeostasis in the lungs and increases the iron content in the airways of smokers. The airway epithelia ...

Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

jeu, 08/03/2018 - 01:00
Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD).

Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

jeu, 08/03/2018 - 01:00
Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms o...

Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer

mer, 07/03/2018 - 01:00
Our previous screening study suggested that the cell-adhesions protein Dihydropyrimidinase-like 3 (DPYSL3) was a candidate metastatic lung cancer related molecule. This study aimed to analyze the correlation b...

A phase IIb randomized, chronic-dosing, incomplete block, cross-over study of glycopyrronium, delivered via metered dose inhaler, compared with a placebo and an active control in patients with moderate-to-severe COPD

lun, 05/03/2018 - 01:00
Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). This Phase IIb study investigated...

PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway

ven, 02/03/2018 - 01:00
The contribution of airway remodeling in chronic obstructive pulmonary disease (COPD) has been well documented, with airway smooth muscle cell proliferation and migration playing a role in the remodeling proce...

Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort

ven, 02/03/2018 - 01:00
The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited...

Commenting on “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study” by Jacob A. Winther and colleagues

jeu, 01/03/2018 - 01:00
We would like to comment on the article entitled “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 stud...

Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis

mar, 27/02/2018 - 01:00
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers repo...

Modulation of human airway smooth muscle biology by human adipocytes

mar, 27/02/2018 - 01:00
Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both ‘obese’ animal mo...

Idiopathic pulmonary fibrosis: pathogenesis and management

jeu, 22/02/2018 - 01:00
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor progn...

Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

mar, 20/02/2018 - 01:00
COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical ...

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD

mer, 14/02/2018 - 01:00
The literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations an...

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

mar, 13/02/2018 - 01:00
ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea

lun, 12/02/2018 - 01:00
Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury

jeu, 08/02/2018 - 01:00
Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis

mer, 07/02/2018 - 01:00
A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...