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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 11 min

The natural history of progressive fibrosing interstitial lung diseases

jeu, 14/03/2019 - 01:00
A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phen...

Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study

mar, 12/03/2019 - 01:00
Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, musc...

Effect of pirfenidone in patients with more advanced idiopathic pulmonary fibrosis

mar, 12/03/2019 - 01:00
Data from controlled clinical studies in patients with more advanced idiopathic pulmonary fibrosis (IPF) could inform clinical practice, but they are limited, since this sub-population is usually excluded from...

Investigating the role of circulating CXCR5-expressing CD8+ T-cells as a biomarker for bacterial infection in subjects with pneumonia

mar, 12/03/2019 - 01:00
Recently, lymphoid follicle-confined and circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, which was involved in anti-virus immune response. However, the dynamics ...

Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension

lun, 11/03/2019 - 01:00
In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.

Role of RASEF hypermethylation in cigarette smoke-induced pulmonary arterial smooth muscle remodeling

jeu, 07/03/2019 - 01:00
Pulmonary hypertension (PH) is a progressive and fatal disease. While cigarette smoke can change DNA methylation status, the role of such molecular alterations in smoke-associated PH is unclear.

Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust

jeu, 07/03/2019 - 01:00
Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases....

Prognostic value of serum macrophage migration inhibitory factor levels in pulmonary tuberculosis

mer, 06/03/2019 - 01:00
Macrophage migration inhibitory factor (MIF) makes chemokine-like functions and plays critical roles in various inflammatory diseases. This study was designed to explore the significance of MIF serum levels in...

The pathology of small airways disease in COPD: historical aspects and future directions

lun, 04/03/2019 - 01:00
Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin...

Down-regulation of microRNA-144-3p and its clinical value in non-small cell lung cancer: a comprehensive analysis based on microarray, miRNA-sequencing, and quantitative real-time PCR data

lun, 04/03/2019 - 01:00
Previous studies have shown that miR-144-3p might be a potential biomarker in non-small cell lung cancer (NSCLC). Nevertheless, the comprehensive mechanism behind the effects of miR-144-3p on the origin, diffe...

Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis

ven, 01/03/2019 - 01:00
Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of ...

The composition of the pulmonary microbiota in sarcoidosis – an observational study

jeu, 28/02/2019 - 01:00
Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim o...

Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values

jeu, 28/02/2019 - 01:00
We developed a method to calculate a standard score for lung tissue mass derived from CT scan images from a control group without respiratory disease. We applied the method to images from subjects with emphyse...

Extent, trends, and determinants of controller/reliever balance in mild asthma: a 14-year population-based study

jeu, 28/02/2019 - 01:00
The majority of patients with asthma have the mild form of the disease. Whether mild asthma patients receive appropriate asthma medications has not received much attention in the literature. We examined the tr...

Prognostic impact of residual SYNTAX score in patients with obstructive sleep apnea and acute coronary syndrome: a prospective cohort study

jeu, 28/02/2019 - 01:00
There is a paucity of data from large prospective study evaluating the prognostic significance of the residual Synergy between percutaneous intervention with Taxus drug-eluting stents and cardiac surgery (SYNT...

Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension

mer, 27/02/2019 - 01:00
Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascula...

Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system

mar, 26/02/2019 - 01:00
Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The...

Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea

ven, 22/02/2019 - 01:00
Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS u...

An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial

ven, 22/02/2019 - 01:00
Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Saffron has anti-inflammatory effects and may has beneficial effects on asthma.

Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis

jeu, 21/02/2019 - 01:00
Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of s...