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Most Recent Articles: Respiratory Research
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Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

mar, 27/03/2018 - 02:00
Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative st...

Regulation of alveolar macrophage death in acute lung inflammation

mar, 27/03/2018 - 02:00
Acute lung injury (ALI) and its severe form, known as acute respiratory distress syndrome (ARDS), are caused by direct pulmonary insults and indirect systemic inflammatory responses that result from conditions...

Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

mar, 27/03/2018 - 02:00
Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the ...

Physical activity in the morning and afternoon is lower in patients with chronic obstructive pulmonary disease with morning symptoms

mar, 27/03/2018 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) experience symptoms that vary over the day. Symptoms at the start of the day might influence physical activity during the rest of the day. Therefore, ...

Prediction equations of forced oscillation technique: the insidious role of collinearity

mar, 27/03/2018 - 02:00
Many studies have reported reference data for forced oscillation technique (FOT) in healthy children. The prediction equation of FOT parameters were derived from a multivariable regression model examining the ...

Integrative genomics identifies new genes associated with severe COPD and emphysema

jeu, 22/03/2018 - 01:00
Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability...

G908R NOD2 variant in a family with sarcoidosis

mar, 20/03/2018 - 01:00
Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis

mar, 20/03/2018 - 01:00
Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in bo...

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

ven, 16/03/2018 - 01:00
Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the...

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance

sam, 10/03/2018 - 01:00
Smoking is a leading cause of respiratory infections worldwide. Tobacco particulate matter disrupts iron homeostasis in the lungs and increases the iron content in the airways of smokers. The airway epithelia ...

Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

jeu, 08/03/2018 - 01:00
Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD).

Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

jeu, 08/03/2018 - 01:00
Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms o...

Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer

mer, 07/03/2018 - 01:00
Our previous screening study suggested that the cell-adhesions protein Dihydropyrimidinase-like 3 (DPYSL3) was a candidate metastatic lung cancer related molecule. This study aimed to analyze the correlation b...

A phase IIb randomized, chronic-dosing, incomplete block, cross-over study of glycopyrronium, delivered via metered dose inhaler, compared with a placebo and an active control in patients with moderate-to-severe COPD

lun, 05/03/2018 - 01:00
Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) bronchodilators are key to the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). This Phase IIb study investigated...

PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway

ven, 02/03/2018 - 01:00
The contribution of airway remodeling in chronic obstructive pulmonary disease (COPD) has been well documented, with airway smooth muscle cell proliferation and migration playing a role in the remodeling proce...

Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort

ven, 02/03/2018 - 01:00
The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited...

Commenting on “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study” by Jacob A. Winther and colleagues

jeu, 01/03/2018 - 01:00
We would like to comment on the article entitled “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 stud...

Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis

mar, 27/02/2018 - 01:00
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers repo...

Modulation of human airway smooth muscle biology by human adipocytes

mar, 27/02/2018 - 01:00
Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both ‘obese’ animal mo...

Idiopathic pulmonary fibrosis: pathogenesis and management

jeu, 22/02/2018 - 01:00
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor progn...