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Most Recent Articles: Respiratory Research
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Immunohistological features related to functional impairment in lymphangioleiomyomatosis

mar, 08/05/2018 - 02:00
Lymphangioleiomyomatosis (LAM) is a low-grade neoplasm characterized by the pulmonary infiltration of smooth muscle-like cells (LAM cells) and cystic destruction. Patients usually present with airway obstructi...

Trends in mortality from pneumonia in the Europe union: a temporal analysis of the European detailed mortality database between 2001 and 2014

ven, 04/05/2018 - 02:00
Pneumonia is responsible for approximately 230,000 deaths in Europe, annually. Comprehensive and comparable reports on pneumonia mortality trends across the European Union (EU) are lacking.

A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia

ven, 04/05/2018 - 02:00
Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease a...

Pollution and respiratory disease: can diet or supplements help? A review

mer, 02/05/2018 - 02:00
Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world’s largest environmental health risk factor. There has be...

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

mer, 02/05/2018 - 02:00
Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implic...

Correction to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

lun, 30/04/2018 - 02:00
In the original publication [1] is an error in table 1. The correct version can be found in this Erratum:

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

ven, 27/04/2018 - 02:00
To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK.

Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects

ven, 27/04/2018 - 02:00
In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify...

Associations between comorbidities, their treatment and survival in patients with interstitial lung diseases – a claims data analysis

mer, 25/04/2018 - 02:00
Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with variou...

Rituximab for auto-immune alveolar proteinosis, a real life cohort study

mer, 25/04/2018 - 02:00
Whole lung lavage is the current standard therapy for pulmonary alveolar proteinosis (PAP) that is characterized by the alveolar accumulation of surfactant. Rituximab showed promising results in auto-immune PA...

Resolution of bleomycin-induced murine pulmonary fibrosis via a splenic lymphocyte subpopulation

mar, 24/04/2018 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+CD25+FoxP3+ regulatory ...

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer

mar, 24/04/2018 - 02:00
Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death...

Correction to: Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis

mar, 24/04/2018 - 02:00
In the original publication [1] is an incorrect sentence in the abstract under Conclusions.

Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

lun, 23/04/2018 - 02:00
Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possibl...

Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

ven, 20/04/2018 - 02:00
Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug disposition, the localization of MATE1, P-gp, OCTN1 and...

FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis

jeu, 19/04/2018 - 02:00
In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we...

Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state

mer, 18/04/2018 - 02:00
Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternativ...

Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways

jeu, 12/04/2018 - 02:00
Corticosteroids increase the expression of β2-adrenoceptors (β2-ARs) and protect them against down-regulation. Conversely, β2-AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it ...

Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort

jeu, 12/04/2018 - 02:00
The imbalance between proteases and anti-proteases is considered to contribute to the development of COPD. Our aim was to evaluate the protease MMP-9, the antiprotease TIMP-1 and the MMP-9/TIMP-1-ratio as biom...

Assessing the healthcare resource use associated with inappropriate prescribing of inhaled corticosteroids for people with chronic obstructive pulmonary disease (COPD) in GOLD groups A or B: an observational study using the Clinical Practice Research...

mer, 11/04/2018 - 02:00
Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencin...