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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 43 min

Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial

lun, 05/08/2019 - 02:00
Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obs...

Mass spectrometry imaging as a tool for evaluating the pulmonary distribution of exogenous surfactant in premature lambs

lun, 05/08/2019 - 02:00
The amount of surfactant deposited in the lungs and its overall pulmonary distribution determine the therapeutic outcome of surfactant replacement therapy. Most of the currently available methods to determine ...

Identification of genetic factors underlying persistent pulmonary hypertension of newborns in a cohort of Chinese neonates

lun, 05/08/2019 - 02:00
Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

Can medicines development improve outcomes in asthma and chronic obstructive pulmonary disease management by driving effectiveness?

ven, 02/08/2019 - 02:00
Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

Defining a role for lung function associated gene GSTCD in cell homeostasis

jeu, 01/08/2019 - 02:00
Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD)

mar, 30/07/2019 - 02:00
Metabolic adaptation in immune cells is necessary to modulate immune cell function as it is intricately coupled with intracellular metabolism. We aimed to characterize the metabolic state of human peripheral b...

Neutrophil elastase as a biomarker for bacterial infection in COPD

mar, 30/07/2019 - 02:00
Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

Mepolizumab reduces exacerbations in patients with severe eosinophilic asthma, irrespective of body weight/body mass index: meta-analysis of MENSA and MUSCA

mar, 30/07/2019 - 02:00
We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling

lun, 29/07/2019 - 02:00
Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosi...

Bone and ocular safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a 52-week randomized study

lun, 29/07/2019 - 02:00
Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate...

Pulmonary rehabilitation, physical activity and aortic stiffness in COPD

mer, 24/07/2019 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in card...

Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model

mer, 24/07/2019 - 02:00
Complement factor C5 can either aggravate or attenuate the T-helper type 2 (TH2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phas...

The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer

lun, 22/07/2019 - 02:00
Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about t...

Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-β1/Smad3 signaling pathway

lun, 22/07/2019 - 02:00
Pulmonary fibrosis is a progressive and irreversible disease for which therapeutic options are currently limited. A recent in vivo study showed that tenofovir, a nucleotide analogue reverse transcriptase inhib...

Use of precision cut lung slices as a translational model for the study of lung biology

ven, 19/07/2019 - 02:00
Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessari...

DSP variants may be associated with longitudinal change in quantitative emphysema

ven, 19/07/2019 - 02:00
Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS)...

Peak expiratory flow as an endpoint for clinical trials in asthma: a comparison with FEV1

jeu, 18/07/2019 - 02:00
The primary lung function endpoint in clinical trials in adolescent and adult patients with asthma is usually forced expiratory volume in one second (FEV1). The objective of our analysis was to assess whether pea...

Tracing exogenous surfactant in vivo in rabbits by the natural variation of 13C

jeu, 18/07/2019 - 02:00
Respiratory Distress Syndrome (RDS) is a prematurity-related breathing disorder caused by a quantitative deficiency of pulmonary surfactant. Surfactant replacement therapy is effective for RDS newborns, althou...

Bronchial thermoplasty increases airway volume measured by functional respiratory imaging

mar, 16/07/2019 - 02:00
The purpose of this study was to use CT scanning with computational fluid dynamics to evaluate the mechanisms by which Bronchial Thermoplasty (BT) improves asthmatic symptoms.

Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD

mar, 16/07/2019 - 02:00
Chronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship betwe...