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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 25 min

A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in...

lun, 03/06/2019 - 02:00
Antidepressants are used both for treating acute episodes and for prophylaxis to prevent future episodes of depression, also called maintenance treatment. This article describes the protocol for a randomised c...

Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

lun, 03/06/2019 - 02:00
Melanoma is common; 15,906 people in the UK were diagnosed with melanoma in 2015 and incidence has increased fivefold in 30 years. Melanoma affects old and young people, with poor prognosis once metastatic. UK...

Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

lun, 03/06/2019 - 02:00
Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously ...

The acquisition of long-lived memory B cell responses to merozoite surface protein-8 in individuals with Plasmodium vivax infection

ven, 31/05/2019 - 02:00
The ability of a malaria antigen to induce effective, long-lasting immune responses is important for the development of a protective malaria vaccine. Plasmodium vivax merozoite surface protein-8 (PvMSP8) has been...

Real-time foot clearance biofeedback to assist gait rehabilitation following stroke: a randomized controlled trial protocol

ven, 31/05/2019 - 02:00
The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum toe clearance (MTC) is the...

RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials

ven, 31/05/2019 - 02:00
A malaria vaccine as part of the integrated malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot implementa...

Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind,...

ven, 31/05/2019 - 02:00
Taurine (Tau) is involved in many biochemical functions such as regulation of glucose and lipid metabolism, enhancement of energy expenditure, anti-inflammatory effects and appetite control. The most important...

Who says “no” to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program

ven, 31/05/2019 - 02:00
Successful stroke trials require adequate recruitment. In this observational study, we assessed reasons for refusal to provide informed consent in eligible patients approached for clinical trial participation ...

Anesthetics to Prevent Lung Injury in Cardiac Surgery (APLICS): a protocol for a randomized controlled trial

ven, 31/05/2019 - 02:00
Patients undergoing cardiac surgery with cardiopulmonary bypass are at an increased risk of developing postoperative pulmonary complications, potentially leading to excess morbidity and mortality. It is likely...

Efficacy and safety of dupilumab for the treatment of uncontrolled asthma: a meta-analysis of randomized clinical trials

ven, 31/05/2019 - 02:00
Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and ...

Reliability, validity and responsiveness of E-RS:COPD in patients with spirometric asthma-COPD overlap

ven, 31/05/2019 - 02:00
The Evaluating Respiratory Symptoms in Chronic Obstructive Pulmonary Disease (E-RS:COPD) is a patient-reported diary that assesses respiratory symptoms in stable COPD.

The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

jeu, 30/05/2019 - 02:00
The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. As a highly conserved cellul...

Using mid-infrared spectroscopy and supervised machine-learning to identify vertebrate blood meals in the malaria vector, Anopheles arabiensis

jeu, 30/05/2019 - 02:00
The propensity of different Anopheles mosquitoes to bite humans instead of other vertebrates influences their capacity to transmit pathogens to humans. Unfortunately, determining proportions of mosquitoes that ha...

Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry

jeu, 30/05/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships...

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites

mer, 29/05/2019 - 02:00
Whole parasite vaccination is an efficacious strategy to induce sterile immunity and to prevent malaria transmission. Understanding the mechanism and response of immune cells to vaccines plays a critical role ...

HEVC double compression detection under different bitrates based on TU partition type

mer, 29/05/2019 - 02:00
During the process of authenticating the integrity of digital videos, double compression is an important evidence. High-efficiency video coding (HEVC) is the latest coding standard proposed in 2013 and has sho...

Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis

mer, 29/05/2019 - 02:00
Tumor chemo-resistance is a hallmark of malignant tumors as well as the major cause of poor survival rates in lung cancer. Transmembrane-4 L-six family member-1 (TM4SF1), an antigen that serves as an oncogene, ma...

Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China

mar, 28/05/2019 - 02:00
Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) ...

Correction to: Ten years malaria trend at Arjo-Didessa sugar development site and its vicinity, Southwest Ethiopia: a retrospective study

mar, 28/05/2019 - 02:00
Following publication of the original article [1], it came to the authors’ attention that unfortunately the last name of one of the authors is spelled incorrectly in the published article.

Efficient single image dehazing by modifying the dark channel prior

mar, 28/05/2019 - 02:00
Outdoor images can be degraded due to the particles in the air that absorb and scatter light. The produced degradation generates contrast attenuation, blurring, and distortion in pixels, resulting in low visib...