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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 43 min

Prevalence and course of disease after lung resection in primary ciliary dyskinesia: a cohort & nested case-control study

mer, 18/09/2019 - 02:00
Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in ...

Determination of reliable lung function parameters in intubated mice

sam, 14/09/2019 - 02:00
Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. Lung function measurement is a key step i...

Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease

ven, 13/09/2019 - 02:00
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and asthma are associated with a variety of precipitating factors including infection. This study assessed the infective viral etiologies b...

Is the 2013 American Thoracic Society CPAP-tracking system algorithm useful for managing non-adherence in long-term CPAP-treated patients?

jeu, 12/09/2019 - 02:00
Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capaci...

Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension

jeu, 12/09/2019 - 02:00
Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Pr...

Factors leading to failure to diagnose pulmonary malignant tumors using endobronchial ultrasound with guide sheath within the target lesion

jeu, 12/09/2019 - 02:00
The diagnostic yield of peripheral pulmonary lesions has significantly increased with the use of radial endobronchial ultrasound with guide sheath within the lesion. Here, we retrospectively evaluated factors ...

Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation

mer, 11/09/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) pathogenesis involves multiple pathways, and combined antifibrotic therapy is needed for future IPF therapy. Inhaled interferon-γ (IFN-γ) was recently shown to be safe and w...

Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat

ven, 06/09/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a dismal prognosis. The average life expectancy of untreated patients with IPF is only 3 to 4 years. Decline in forced vital capacity (FVC) in ...

Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells

ven, 06/09/2019 - 02:00
Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into Type 1 alveolar epithelial cells (AT1s). In the prese...

High level of fluorescent oxidation products and worsening of asthma control over time

ven, 06/09/2019 - 02:00
High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has nev...

Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer

mar, 03/09/2019 - 02:00
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death in the world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate cancer pr...

Lyn regulates epithelial–mesenchymal transition in CS-exposed model through Smad2/3 signaling

lun, 02/09/2019 - 02:00
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for CO...

Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice

lun, 02/09/2019 - 02:00
Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronc...

Validation of the IPF-specific version of St. George’s Respiratory Questionnaire

mer, 28/08/2019 - 02:00
Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was develo...

Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study

mer, 28/08/2019 - 02:00
There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations ...

The interleukin-33 receptor contributes to pulmonary responses to ozone in male mice: role of the microbiome

mar, 27/08/2019 - 02:00
Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness i...

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

ven, 23/08/2019 - 02:00
The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

Circulating neutrophils levels are a predictor of pneumonia risk in chronic obstructive pulmonary disease

ven, 23/08/2019 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7)

ven, 23/08/2019 - 02:00
The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study

ven, 23/08/2019 - 02:00
It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...