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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 8 min

Effect of continuous positive airway pressure on long-term cardiovascular outcomes in patients with coronary artery disease and obstructive sleep apnea: a systematic review and meta-analysis

mar, 10/04/2018 - 02:00
Obstructive sleep apnea (OSA) is highly prevalent in patients with coronary artery disease (CAD) and is associated with recurrent cardiovascular risk. However, whether treatment with continuous positive airway...

Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study

mar, 10/04/2018 - 02:00
It is unknown if the plasma lipidome is a useful tool for improving our understanding of the acute respiratory distress syndrome (ARDS). Therefore, we measured the plasma lipidome of individuals with ARDS at t...

Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress

mar, 10/04/2018 - 02:00
Chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in world. Cigarette smoke is known to cause oxidative stress and deplete glutathione (GSH) levels. Nuclear erythroid-rel...

Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution

mar, 10/04/2018 - 02:00
Gastric contents aspiration in humans has variable consequences depending on the volume of aspirate, ranging from subclinical pneumonitis to respiratory failure with up to 70% mortality. Several experimental a...

The genetics of smoking in individuals with chronic obstructive pulmonary disease

mar, 10/04/2018 - 02:00
Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the gene...

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response

sam, 07/04/2018 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to e...

A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

mer, 04/04/2018 - 02:00
A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, th...

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

lun, 02/04/2018 - 02:00
Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway sm...

Airway disease phenotypes in animal models of cystic fibrosis

lun, 02/04/2018 - 02:00
In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered i...

Oxidative stress enhances the expression of IL-33 in human airway epithelial cells

mar, 27/03/2018 - 02:00
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be ...

Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

mar, 27/03/2018 - 02:00
Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative st...

Regulation of alveolar macrophage death in acute lung inflammation

mar, 27/03/2018 - 02:00
Acute lung injury (ALI) and its severe form, known as acute respiratory distress syndrome (ARDS), are caused by direct pulmonary insults and indirect systemic inflammatory responses that result from conditions...

Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

mar, 27/03/2018 - 02:00
Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis. Thus, the ...

Physical activity in the morning and afternoon is lower in patients with chronic obstructive pulmonary disease with morning symptoms

mar, 27/03/2018 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) experience symptoms that vary over the day. Symptoms at the start of the day might influence physical activity during the rest of the day. Therefore, ...

Prediction equations of forced oscillation technique: the insidious role of collinearity

mar, 27/03/2018 - 02:00
Many studies have reported reference data for forced oscillation technique (FOT) in healthy children. The prediction equation of FOT parameters were derived from a multivariable regression model examining the ...

Integrative genomics identifies new genes associated with severe COPD and emphysema

jeu, 22/03/2018 - 01:00
Genome-wide association studies have identified several genetic risk loci for severe chronic obstructive pulmonary disease (COPD) and emphysema. However, these studies do not fully explain disease heritability...

G908R NOD2 variant in a family with sarcoidosis

mar, 20/03/2018 - 01:00
Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis

mar, 20/03/2018 - 01:00
Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in bo...

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

ven, 16/03/2018 - 01:00
Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the...

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance

sam, 10/03/2018 - 01:00
Smoking is a leading cause of respiratory infections worldwide. Tobacco particulate matter disrupts iron homeostasis in the lungs and increases the iron content in the airways of smokers. The airway epithelia ...