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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 25 min

Estimation of gait normality index based on point clouds through deep auto-encoder

mar, 28/05/2019 - 02:00
This paper proposes a method estimating an index that indicates human gait normality based on a sequence of 3D point clouds representing the walking motion of a subject. A cylinder-based histogram is extracted...

Assessment of food insecurity and its determinants in the rural households in Damot Gale Woreda, Wolaita zone, southern Ethiopia

mar, 28/05/2019 - 02:00
Food insecurity is directly related to poverty at global, regional, national and local levels. FAO’s most recent estimates indicate that globally, 842 million people were unable to meet their dietary energy re...

Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time

mar, 28/05/2019 - 02:00
We developed subclone multiplicity allocation and somatic heterogeneity (SMASH), a new statistical method for intra-tumor heterogeneity (ITH) inference. SMASH is tailored to the purpose of large-scale associat...

Prognostic value of B cells in cutaneous melanoma

mar, 28/05/2019 - 02:00
Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and ...

Somatic mutation and clonal expansions in human tissues

mar, 28/05/2019 - 02:00
Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment ...

Clinical utility of custom-designed NGS panel testing in pediatric tumors

mar, 28/05/2019 - 02:00
Somatic genetic testing is rapidly becoming the standard of care in many adult and pediatric cancers. Previously, the standard approach was single-gene or focused multigene testing, but many centers have moved...

A novel camera path planning algorithm for real-time video stabilization

lun, 27/05/2019 - 02:00
In video stabilization, a steady camera path plan is as important as accurate camera motion prediction. While several camera path planning algorithms have been studied, most algorithms are used for post-proces...

Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine

lun, 27/05/2019 - 02:00
To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in ch...

Reconstruction for block-based compressive sensing of image with reweighted double sparse constraint

ven, 24/05/2019 - 02:00
Block compressive sensing reduces the computational complexity by dividing the image into multiple patches for processing, but the performance of the reconstruction algorithm is decreased. Generally, the recon...

Dissecting lung development and fibrosis at single-cell resolution

ven, 24/05/2019 - 02:00
Single-cell transcriptome profiling has enabled high-resolution analysis of cellular populations in tissues during development, health, and disease. Recent studies make innovative use of single-cell RNA sequen...

The CpxR regulates type VI secretion system 2 expression and facilitates the interbacterial competition activity and virulence of avian pathogenic Escherichia coli

ven, 24/05/2019 - 02:00
Systemic infections caused by avian pathogenic Escherichia coli (APEC) are economically devastating to poultry industries worldwide and are also potentially threatening to human health. Pathogens must be able to ...

Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration

ven, 24/05/2019 - 02:00
Helicobacter suis has been associated with development of gastric ulcers in the non-glandular part of the porcine stomach, possibly by affecting gastric acid secretion and altering the gastric microbiota. Fusobac...

Risk factors for diagnostic delay in idiopathic pulmonary fibrosis

ven, 24/05/2019 - 02:00
Surveys and retrospective studies of patients with idiopathic pulmonary fibrosis (IPF) have shown a significant diagnostic delay. However, the causes and risk factors for this delay are not known.

Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma

ven, 24/05/2019 - 02:00
Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypot...

Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

jeu, 23/05/2019 - 02:00
The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry,...

Correlation between footpad lesions and systemic bacterial infections in broiler breeders

mer, 22/05/2019 - 02:00
Footpad lesions are an important factor in evaluation of animal welfare in broilers regulated by law; however, no legal requirements have been set for the parent birds. Nevertheless, the present study confirms...

Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and...

mer, 22/05/2019 - 02:00
The fusogenically activated F and HN proteins of virulent NDV induce complete autophagic flux in DF-1 and A549 cells. However, the effect of both glycoproteins on mitochondria remains elusive. Here, we found t...

Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies

mer, 22/05/2019 - 02:00
A longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, ...

Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

mer, 22/05/2019 - 02:00
Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin serum levels. Interestingly, patients with Chronic Obstr...

Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study

mer, 22/05/2019 - 02:00
Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25–75% (FEF25–75) measured at age 10, 18, and ...