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Most Recent Articles: Respiratory Research
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Bronchial thermoplasty: activations predict response

mar, 04/07/2017 - 02:00
Bronchial thermoplasty (BT) is an emerging bronchoscopic intervention for the treatment of severe asthma. The predictive factors for clinical response to BT are unknown. We examined the relationship between th...

Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?

lun, 03/07/2017 - 02:00
The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of inflammat...

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

ven, 30/06/2017 - 02:00
Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provi...

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation

mer, 28/06/2017 - 02:00
Azithromycin, an antibiotic used for multiple infectious disorders, exhibits anti-inflammatory effects, but the molecular basis for this activity is not well characterized. Azithromycin inhibits IL-1β-mediated...

Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea

mer, 28/06/2017 - 02:00
Obstructive sleep apnea is characterized by intermittent hypoxia and hypercapnia. CO2 production, transport and elimination are influenced by the carbonic anhydrase enzyme. We hypothesized that elevated standard ...

Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero

mar, 27/06/2017 - 02:00
An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in ute...

The cost of systemic corticosteroid-induced morbidity in severe asthma: a health economic analysis

lun, 26/06/2017 - 02:00
Treatment of severe asthma may include high dose systemic-steroid therapy which is associated with substantial additional morbidity. This study estimates the additional healthcare costs associated with steroid...

Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells

lun, 26/06/2017 - 02:00
Tuberculosis (TB) is one of the most common infectious diseases worldwide. During active tuberculosis, T helper (Th) 17 cells are decreased, however the association with inhibitory immune regulation is unclear.

Role of P2X7R in the development and progression of pulmonary hypertension

sam, 24/06/2017 - 02:00
Pulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes ...

Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release

mer, 21/06/2017 - 02:00
β2-adrenoceptor agonists have been shown to reduce the lipopolysaccharide (LPS)-induced cytokine release by human monocyte-derived macrophages (MDMs). We compare the expression of β2-adrenoceptors and the inhibit...

Optimizing bronchodilation in the prevention of COPD exacerbations

mar, 20/06/2017 - 02:00
The natural disease course of chronic obstructive pulmonary disease (COPD) is often punctuated by exacerbations: acute events of symptom worsening associated with significant morbidity and healthcare resource ...

Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD)

lun, 19/06/2017 - 02:00
Beta-blockers are commonly prescribed for patients with cardiovascular disease. Providers have been wary of treating chronic obstructive pulmonary disease (COPD) patients with beta-blockers due to concern for ...

Forced expiration measurements in mouse models of obstructive and restrictive lung diseases

lun, 19/06/2017 - 02:00
Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these para...

Fibroblast paracrine TNF-α signaling elevates integrin A5 expression in idiopathic pulmonary fibrosis (IPF)

lun, 19/06/2017 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. Inflammatory cytokines play a significant role in IPF pathology. However, the fibroblast itself is also believed to be t...

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

jeu, 15/06/2017 - 02:00
Primitive lung cancers developed on lung fibroses are both diagnostic and therapeutic challenges. Their incidence may increase with new more efficient lung fibrosis treatments. Our aim was to describe a cohort...

Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO

jeu, 15/06/2017 - 02:00
Long-term survival of lung transplantation is hindered by the development of obliterative bronchiolitis (OB). Adipose-derived stem cells (ASCs) were documented to have more potent immunosuppressive ability tha...

Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression

jeu, 15/06/2017 - 02:00
The influence of lung fibroblasts on lung cancer progression is not fully understood.

Multiple biomarkers predict disease severity, progression and mortality in COPD

mar, 13/06/2017 - 02:00
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severit...