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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 49 min

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

sam, 21/12/2019 - 01:00
Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated...

The effectiveness of Reslizumab in severe asthma treatment: a real-world experience

ven, 20/12/2019 - 01:00
Increased numbers of blood and sputum eosinophils are associated with higher exacerbation frequency and increased asthma severity. In clinical trials, targeting Interleukin-5 has been shown to be a useful ther...

Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study

jeu, 19/12/2019 - 01:00
Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection during childhood may polarise the immune system towards...

Prognostic differences among patients with idiopathic interstitial pneumonias with acute exacerbation of varying pathogenesis: a retrospective study

mer, 18/12/2019 - 01:00
Acute exacerbation of chronic fibrosing idiopathic interstitial pneumonias (AE-IIPs) is associated with a high mortality rate. In 2016, an international working group proposed a revised diagnostic criteria for...

Clinical characteristics and treatment outcomes of patients with macrolide-resistant Mycobacterium avium complex pulmonary disease: a systematic review and meta-analysis

mer, 18/12/2019 - 01:00
Macrolide is a key drug in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Macrolide-resistant MAC is gaining importance, but there are little data in clinical characteristics and treatme...

Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice

mer, 18/12/2019 - 01:00
β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (....

Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens

mer, 18/12/2019 - 01:00
Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated ...

Comparative analyses of long non-coding RNA profiles in vivo in cystic fibrosis lung airway and parenchyma tissues

lun, 16/12/2019 - 01:00
Recent advances in the functional analyses of endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs), have provided a new perspective on the crucial roles of RNA in gene regulati...

The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study

lun, 16/12/2019 - 01:00
There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of...

Upregulation of MUC5AC by VEGF in human primary bronchial epithelial cells: implications for asthma

jeu, 12/12/2019 - 01:00
Airway mucus hypersecretion is an important pathophysiological feature in asthma. Mucins are glycoproteins that are mainly responsible for the viscoelastic property of mucus, and MUC5AC is a major mucin glycop...

Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression

mer, 11/12/2019 - 01:00
Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has bee...

Threshold of the upper airway cross-section for hypopnea onset during sleep and its identification under waking condition

mer, 11/12/2019 - 01:00
There is currently no method that can predict whether or under what condition hypopnea, even obstructive sleep apnea (OSA), will occur during sleep for individuals based on credible parameters measured under w...

Serum bilirubin level is associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

lun, 09/12/2019 - 01:00
Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical paramet...

Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients

jeu, 05/12/2019 - 01:00
Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). T...

Inhaled corticosteroids and FEV1 decline in chronic obstructive pulmonary disease: a systematic review

mer, 04/12/2019 - 01:00
Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and no...

Excessive daytime sleepiness, metabolic syndrome, and obstructive sleep apnea: two independent large cross-sectional studies and one interventional study

mer, 04/12/2019 - 01:00
Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scal...

Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center

mer, 04/12/2019 - 01:00
Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasi...

Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques

mer, 04/12/2019 - 01:00
By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also co...

Does a tailored intervention to promote adherence in patients with chronic lung disease affect exacerbations? A randomized controlled trial

mar, 03/12/2019 - 01:00
Poor medication-adherence is common in chronic lung patients, resulting in reduced health-outcomes and increased healthcare-costs. This study aimed to investigate the impact of an acoustic reminder and support...

Dysbiosis of lower respiratory tract microbiome are associated with inflammation and microbial function variety

mar, 03/12/2019 - 01:00
Lower respiratory tract (LRT) microbiome has been reported to associate with pulmonary diseases. Unregulated inflammation is an underlying cause of variable lung diseases. The lung microbiome may play an impor...