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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 23 min

Consequences of chronic kidney disease in chronic obstructive pulmonary disease

ven, 12/07/2019 - 02:00
The combination of chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) is associated with a higher prevalence of comorbidities and increased mortality. The impact of kidney function o...

Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells

ven, 12/07/2019 - 02:00
Human rhinovirus (HRV) infections are the primary cause of the common cold and are a major trigger for exacerbations of lower airway diseases, such as asthma and chronic obstructive pulmonary diseases. Althoug...

Dose variability of supplemental oxygen therapy with open patient interfaces based on in vitro measurements using a physiologically realistic upper airway model

ven, 12/07/2019 - 02:00
Supplemental oxygen therapy is widely used in hospitals and in the home for chronic care. However, there are several fundamental problems with the application of this therapy such that patients are often expos...

Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort

ven, 12/07/2019 - 02:00
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying ...

Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains

mer, 10/07/2019 - 02:00
Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and...

Do blood eosinophils strictly reflect airway inflammation in COPD? Comparison with asthmatic patients

mer, 10/07/2019 - 02:00
Airway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; howe...

Chronic obstructive pulmonary disease in rheumatoid arthritis: a systematic review and meta-analysis

mar, 09/07/2019 - 02:00
The risk and prevalence of chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis (RA) is still obscure. The current study was aimed to systematically review and meta-analyse the risk ratio (RR) ...

COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population

lun, 08/07/2019 - 02:00
Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate t...

Feasibility of low dose chest CT for virtual bronchoscopy navigation in a porcine model

lun, 08/07/2019 - 02:00
Virtual bronchoscopy navigation (VBN) is widely used for assistance in the histological examination of lung nodules. However, little is known about the optimal CT radiation dose for VBN. Therefore, we performe...

Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective

lun, 08/07/2019 - 02:00
There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1...

Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease – a prospective, randomized, multicentre cross-over trial

ven, 05/07/2019 - 02:00
Bronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenc...

Ambient air pollution and respiratory mortality in Xi’an, China: a time-series analysis

ven, 05/07/2019 - 02:00
Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The s...

Pleural thickening on screening chest X-rays: a single institutional study

ven, 05/07/2019 - 02:00
Although pleural thickening is a common finding on routine chest X-rays, its radiological and clinical features remain poorly characterized. Our investigation of 28,727 chest X-rays obtained from annual health...

Pulmonary gas exchange in hereditary hemorrhagic telangiectasia patients with liver arteriovenous malformations

jeu, 04/07/2019 - 02:00
The severity of Hereditary Hemorrhagic Telangiectasia (HHT) disease is generally related to vascular visceral involvement represented by arteriovenous malformations (AVMs). Pulmonary function tests (PFTs) rema...

Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer

jeu, 04/07/2019 - 02:00
The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors fo...

Effect of smoking status on lung function, patient-reported outcomes, and safety among COPD patients treated with glycopyrrolate inhalation powder: pooled analysis of GEM1 and GEM2 studies

mar, 02/07/2019 - 02:00
Smoking is a major risk factor for COPD and may impact the efficacy of COPD treatments; however, a large proportion of COPD patients continue to smoke following diagnosis.

From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy

mar, 02/07/2019 - 02:00
Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical cha...

CFTR regulates B cell activation and lymphoid follicle development

lun, 01/07/2019 - 02:00
Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection and inflammation and progressive loss of lung...

Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease

ven, 28/06/2019 - 02:00
Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who are unable to administer medications efficiently with conventional inhalers may benefit from the use of a n...