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اشترك ب تلقيمة Respiratory research feeds
Most Recent Articles: Respiratory Research
آخر تحديث: منذ ساعتين 52 دقيقة

Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

ثلاثاء, 20/02/2018 - 01:00
COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical ...

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD

أربعاء, 14/02/2018 - 01:00
The literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations an...

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

ثلاثاء, 13/02/2018 - 01:00
ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea

اثنين, 12/02/2018 - 01:00
Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury

خميس, 08/02/2018 - 01:00
Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis

أربعاء, 07/02/2018 - 01:00
A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis

ثلاثاء, 06/02/2018 - 01:00
Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

The JAK2 pathway is activated in idiopathic pulmonary fibrosis

ثلاثاء, 06/02/2018 - 01:00
Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

سبت, 03/02/2018 - 01:00
Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

Long-term preservation of planar cell polarity in reversed tracheal epithelium

جمعة, 02/02/2018 - 01:00
Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts

جمعة, 26/01/2018 - 01:00
Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unk...

miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein

جمعة, 26/01/2018 - 01:00
Abnormal apoptosis of lung endothelial cells has been observed in emphysematous lung tissue and has been suggested to be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease...

Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: a randomized non-inferiority study

خميس, 25/01/2018 - 01:00
Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patie...

Molecular imaging of pulmonary diseases

أربعاء, 24/01/2018 - 01:00
Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential ...

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

أربعاء, 24/01/2018 - 01:00
Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...

Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis

أربعاء, 24/01/2018 - 01:00
We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of long-acting bronchodilators on exercise capacity in COPD patients.

Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

اثنين, 22/01/2018 - 01:00
Accumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution. Their small size facilitates dispersal and subsequent exposur...

Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

خميس, 18/01/2018 - 01:00
Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

خميس, 18/01/2018 - 01:00
Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...

Chronic obstructive pulmonary disease guidelines in Europe: a look into the future

خميس, 18/01/2018 - 01:00
Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guideline...

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