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Most Recent Articles: Respiratory Research
Updated: 2 hours 44 min ago

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

Fri, 08/23/2019 - 02:00
The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

Circulating neutrophils levels are a predictor of pneumonia risk in chronic obstructive pulmonary disease

Fri, 08/23/2019 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7)

Fri, 08/23/2019 - 02:00
The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study

Fri, 08/23/2019 - 02:00
It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Thu, 08/22/2019 - 02:00
Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual an...

Relationship between gender and survival in a real-life cohort of patients with COPD

Thu, 08/22/2019 - 02:00
Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this...

Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

Tue, 08/20/2019 - 02:00
Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response pl...

Are there specific clinical characteristics associated with physician’s treatment choices in COPD?

Tue, 08/20/2019 - 02:00
The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be info...

Circulating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea

Tue, 08/20/2019 - 02:00
Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial d...

A decision tree built with parameters obtained by computed tomographic pulmonary angiography is useful for predicting adverse outcomes in non-high-risk acute pulmonary embolism patients

Mon, 08/19/2019 - 02:00
Acute pulmonary embolism (APE) is one of the leading causes of death in cardiovascular disease. The 30-day mortality can still be 1.7–15% in non-high-risk APE patients. Some non-high-risk patients can progress...

Decline of COPD exacerbations in clinical trials over two decades – a systematic review and meta-regression

Fri, 08/16/2019 - 02:00
An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...

Comparison of tumor cell numbers and 22C3 PD-L1 expression between cryobiopsy and transbronchial biopsy with endobronchial ultrasonography-guide sheath for lung cancer

Fri, 08/16/2019 - 02:00
We previously reported cryobiopsy (Cryo) with endobronchial ultrasonography-guide sheath (EBUS-GS) for peripheral pulmonary lesions (PPLs) provides significantly larger tissues than transbronchial biopsy (TBB)...

IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1

Thu, 08/15/2019 - 02:00
Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for seve...

It is time to change the way we manage mild asthma: an update in GINA 2019

Wed, 08/14/2019 - 02:00
Asthma is a heterogeneous lung disease, usually characterised by chronic airway inflammation. Although evidence-based treatments are available in most countries, asthma control remains suboptimal, and asthma-r...

Myelodysplastic syndromes and idiopathic pulmonary fibrosis: a dangerous liaison

Tue, 08/13/2019 - 02:00
Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study p...

Role of KRAS in regulating normal human airway basal cell differentiation

Fri, 08/09/2019 - 02:00
KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD

Fri, 08/09/2019 - 02:00
CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmon...

Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis

Thu, 08/08/2019 - 02:00
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate. PubMed and Web...

Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

Wed, 08/07/2019 - 02:00
Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, ...

Clinical outcomes of radial probe endobronchial ultrasound using a guide sheath for diagnosis of peripheral lung lesions in patients with pulmonary emphysema

Tue, 08/06/2019 - 02:00
Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesio...