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Most Recent Articles: Respiratory Research
Updated: 1 hour 11 min ago

Anti-bacterial antibody and T cell responses in bronchiectasis are differentially associated with lung colonization and disease

Wed, 05/30/2018 - 02:00
As a way to determine markers of infection or disease informing disease management, and to reveal disease-associated immune mechanisms, this study sought to measure antibody and T cell responses against key lu...

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis

Tue, 05/29/2018 - 02:00
Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been ...

A home monitoring program including real-time wireless home spirometry in idiopathic pulmonary fibrosis: a pilot study on experiences and barriers

Tue, 05/29/2018 - 02:00
In idiopathic pulmonary fibrosis (IPF), home monitoring experiences are limited, not yet real-time available nor implemented in daily care. We evaluated feasibility and potential barriers of a new home monitor...

Is the purinergic pathway involved in the pathology of COPD? Decreased lung CD39 expression at initial stages of COPD

Mon, 05/28/2018 - 02:00
Extracellular adenosine triphosphate (ATP) is up-regulated in the airways of patients with chronic obstructive pulmonary disease (COPD), resulting in increased inflammation, bronchoconstriction, and cough. Alt...

Quality of life assessment in interstitial lung diseases:a comparison of the disease-specific K-BILD with the generic EQ-5D-5L

Fri, 05/25/2018 - 02:00
Patients with interstitial lung diseases (ILD) have impaired health-related quality of life (HRQL). Little is known about the applicability of the disease-specific King’s Brief Interstitial Lung Disease questi...

Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation

Fri, 05/25/2018 - 02:00
Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as poten...

Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease

Thu, 05/24/2018 - 02:00
Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition in which an important extra-pulmonary manifestation is cardiovascular disease. We hypothesized that COPD patients would have inc...

Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Wed, 05/23/2018 - 02:00
Asthma is a chronic respiratory condition, with airway hyperresponsiveness (AHR) and inflammation as hallmarks. The hypothesis that the substantially increased expression of arginase 1 in activated macrophages...

Association of serum bilirubin level with lung function decline: a Korean community-based cohort study

Wed, 05/23/2018 - 02:00
Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function declin...

Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

Mon, 05/21/2018 - 02:00
The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP...

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

Mon, 05/21/2018 - 02:00
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, including gefitinib, are first-line drugs against advanced non-small cell lung cancer with activating EGFR mutations. However, the developmen...

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

Mon, 05/14/2018 - 02:00
Little is known about health risks associated with electronic cigarette (EC) use although EC are rising in popularity and have been advocated as a means to quit smoking cigarettes.

The aging lung: tissue telomere shortening in health and disease

Fri, 05/11/2018 - 02:00
Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently,...

Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline

Fri, 05/11/2018 - 02:00
Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking o...

Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis

Thu, 05/10/2018 - 02:00
Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affe...

Effects and molecular mechanisms of intrauterine infection/inflammation on lung development

Thu, 05/10/2018 - 02:00
Intrauterine infection/inflammation plays an important role in the development of lung injury and bronchopulmonary dysplasia (BPD) in preterm infants, While a multifactorial genesis is likely, mechanisms invol...

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Thu, 05/10/2018 - 02:00
Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of huma...

Modelling the asthma phenotype: impact of cigarette smoke exposure

Thu, 05/10/2018 - 02:00
Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especi...

Association between oncogenic status and risk of venous thromboembolism in patients with non-small cell lung cancer

Wed, 05/09/2018 - 02:00
Preclinical data suggest that oncogene (EGFR and KRAS) events regulate tumor procoagulant activity. However, few studies have prospectively investigated the clinical relevance between the presence of EGFR or K...

Cost-effectiveness of lung volume reduction coil treatment in patients with severe emphysema: results from the 2-year follow-up crossover REVOLENS study (REVOLENS-2 study)

Wed, 05/09/2018 - 02:00
The REVOLENS study compared lung volume reduction coil treatment to usual care in patients with severe emphysema at 1 year, resulting in improved quality-adjusted life-year (QALY) and higher costs. Durability ...