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Most Recent Articles: Respiratory Research
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The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

ven, 03/07/2020 - 02:00
Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seri...

Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19

ven, 03/07/2020 - 02:00
Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of deat...

High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice

jeu, 02/07/2020 - 02:00
Titanium dioxide nanoparticles (TiO2 NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO2 powder are more susce...

CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis

jeu, 02/07/2020 - 02:00
Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their anti-proliferative mode of action, we hypothesized ...

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

mer, 01/07/2020 - 02:00
Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil...

Transcriptomic profiling reveals disease-specific characteristics of epithelial cells in idiopathic pulmonary fibrosis

mar, 30/06/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) is an incurable disease characterized by progressive lung fibrosis ultimately resulting in respiratory failure and death. Recurrent micro-injuries to the alveolar epithelium...

Acute exacerbations of COPD versus IPF in patients with combined pulmonary fibrosis and emphysema

mar, 30/06/2020 - 02:00
Patients with combined pulmonary fibrosis and emphysema (CPFE) may develop acute exacerbations of IPF (AE-IPF) or COPD (AE-COPD). The incidence and the characteristics of exacerbations in patients with CPFE (e...

Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase

lun, 29/06/2020 - 02:00
This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease

ven, 26/06/2020 - 02:00
Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individual...

Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production

ven, 26/06/2020 - 02:00
Cigarette smoke (CS) is a major risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Epithelial-mesenchymal transition (EMT) commonly coexists in lung cancer and COP...

Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses

mar, 23/06/2020 - 02:00
Neutrophil is of the most abundant number in human immune system. During acute influenza virus infection, neutrophils are already active in the early phase of inflammation - a time in which clinical biopsy or ...

Adoption of a dedicated multidisciplinary team is associated with improved survival in acute pulmonary embolism

lun, 22/06/2020 - 02:00
Acute pulmonary embolism remains a significant cause of mortality and morbidity worldwide. Benefit of recently developed multidisciplinary PE response teams (PERT) with higher utilization of advanced therapies...

Improving the evaluation of COPD exacerbation treatment effects by accounting for early treatment discontinuations: a post-hoc analysis of randomized clinical trials

lun, 22/06/2020 - 02:00
Chronic obstructive pulmonary disease (COPD) clinical trials aimed at evaluating treatment effects on exacerbations often suffer from early discontinuations of randomized treatment. Treatment discontinuations ...

Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study

lun, 22/06/2020 - 02:00
Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

Performance of brief ICF-sleep disorders and obesity core set in obstructive sleep apnea patients

lun, 22/06/2020 - 02:00
Clinical questionnaires are mainly applied as screening tools for identification of the Obstructive sleep apnea (OSA) patients. Little attention has been paid to assess the body functions and health status of ...

T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles

ven, 19/06/2020 - 02:00
Asthma is a common and heterogeneous disease that includes subgroups characterized by type 2 (T2) or type 17 (T17) immune responses for which there is a need to identify the underlying mechanisms and biomarker...

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation

jeu, 18/06/2020 - 02:00
Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

The impact of adjuvant surgical treatment of nontuberculous mycobacterial pulmonary disease on prognosis and outcome

mar, 16/06/2020 - 02:00
Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic fa...

Trends and seasonal variation of hospitalization and mortality of interstitial lung disease in the United States from 2006 to 2016

mar, 16/06/2020 - 02:00
In the recent years, the overall trends in hospital admission and mortality of interstitial lung disease (ILD) are unknown. In addition, there was some evidence that interstitial lung disease death rate highes...

Interaction between obstructive sleep apnea and short sleep duration on insulin resistance: a large-scale study

mar, 16/06/2020 - 02:00
Both short sleep duration and obstructive sleep apnea (OSA) seem to be associated with insulin resistance. We aimed to explore whether short sleep duration modifies the relationship between OSA and insulin res...