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Most Recent Articles: Respiratory Research
Mis à jour : il y a 2 heures 56 min

The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia

ven, 17/07/2020 - 02:00
Cystic fibrosis (CF) patients are extremely vulnerable to Burkholderia cepacia complex (Bcc) infections. However, the underlying etiology is poorly understood. We tested the hypothesis that short palate lung and ...

Assessment of comorbidities and prognosis in patients with COPD diagnosed with the fixed ratio and the lower limit of normal: a systematic review and meta-analysis

jeu, 16/07/2020 - 02:00
Currently, the diagnosis of chronic obstructive pulmonary disease (COPD) is not uniform, COPD guidelines recommend fixed ratio (FR), whereas ATS and ERS define airflow obstruction based on lower limit of norma...

ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction

jeu, 16/07/2020 - 02:00
A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known.

Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression

jeu, 16/07/2020 - 02:00
Mesothelioma is histologically divided into three subgroups: epithelioid, sarcomatoid, and biphasic types. The epithelioid or sarcomatoid type is morphologically defined by polygonal or spindle-like forms of c...

In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

jeu, 16/07/2020 - 02:00
The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating multiple genes under such multifactorial ...

The association between pulmonary embolism and the cancer-related genomic alterations in patients with NSCLC

jeu, 16/07/2020 - 02:00
To date, the association between the acute pulmonary embolism (PE) and the currently existing cancer-related genomic alterations in patients with non-small cell lung cancer (NSCLC) has been understudied. We re...

A novel pleural-bladder pump for the management of recurrent malignant pleural effusions: a feasibility animal study

mer, 15/07/2020 - 02:00
Recurrent malignant pleural effusions (MPE) are common and associated with significant morbidity in cancer patients. A new pump connecting the pleural cavity and the bladder may have application for the manage...

The sputum microbiome is distinct between COPD and health, independent of smoking history

mar, 14/07/2020 - 02:00
Airway bacterial dysbiosis is a feature of chronic obstructive pulmonary disease (COPD). However, there is limited comparative data of the lung microbiome between healthy smokers, non-smokers and COPD.

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis

mar, 14/07/2020 - 02:00
Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide, with numbers increasing dramatically daily. However...

Nasal microbiota dominated by Moraxella spp. is associated with respiratory health in the elderly population: a case control study

mar, 14/07/2020 - 02:00
The elderly (≥65 years) are one of the populations most at risk for respiratory tract infections (RTIs). The aim of this study was to determine whether nasal and/or oropharyngeal microbiota profiles are associ...

Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China

mar, 14/07/2020 - 02:00
In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on t...

Relationship between age and bronchodilator response at diagnosis in adult-onset asthma

lun, 13/07/2020 - 02:00
Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma an...

The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

sam, 11/07/2020 - 02:00
Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and m...

Composite endpoints in COPD: clinically important deterioration in the UPLIFT trial

jeu, 09/07/2020 - 02:00
Assessments of lung function, exacerbations and health status are common measures of chronic obstructive pulmonary disease (COPD) progression and treatment response in clinical trials. We hypothesised that a c...

The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma

mer, 08/07/2020 - 02:00
The interleukin 17 receptor E (IL-17RE) is specific for the epithelial cytokine interleukin-17C (IL-17C). Asthma exacerbations are frequently caused by viral infections. Polyinosinic:polycytidylic acid (pIC) m...

Extracellular vesicles: novel communicators in lung diseases

mer, 08/07/2020 - 02:00
The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (E...

Airway-invasion-associated pulmonary computed tomography presentations characteristic of invasive pulmonary Aspergillosis in non-immunocompromised adults: a National Multicenter Retrospective Survey in China

mar, 07/07/2020 - 02:00
The European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria are widely used in the diagnosis of invasive pulmonary aspergillosis (IPA), but they only apply to immuno...

Effect of hypertension on outcomes of adult inpatients with COVID-19 in Wuhan, China: a propensity score–matching analysis

lun, 06/07/2020 - 02:00
Previous studies have shown that Coronavirus Disease 2019 (COVID-19) patients with underlying comorbidities can have worse outcomes. However, the effect of hypertension on outcomes of COVID-19 patients remains...

Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia

lun, 06/07/2020 - 02:00
There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in ...