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Most Recent Articles: Respiratory Research
Mis à jour : il y a 1 heure 23 min

FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients

ven, 08/05/2020 - 02:00
The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

jeu, 07/05/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

Circulating microRNAs correlate to clinical parameters in individuals with allergic and non-allergic asthma

jeu, 07/05/2020 - 02:00
Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients – a retrospective analysis

mer, 06/05/2020 - 02:00
In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...

Differences in airway microbiome and metabolome of single lung transplant recipients

mer, 06/05/2020 - 02:00
Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

Validation of a method to assess emphysema severity by spirometry in the COPDGene study

ven, 01/05/2020 - 02:00
Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells

ven, 01/05/2020 - 02:00
In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

Heme metabolism genes Downregulated in COPD Cachexia

ven, 01/05/2020 - 02:00
Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine

jeu, 30/04/2020 - 02:00
There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

IL-33, diet-induced obesity, and pulmonary responses to ozone

jeu, 23/04/2020 - 02:00
Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...