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Most Recent Articles: Respiratory Research
آخر تحديث: منذ ساعة واحدة 47 دقيقة

FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer

اثنين, 10/08/2020 - 02:00
This study investigated the role of fibrinogen-like protein 1 (FGL1) in regulating gefitinib resistance of PC9/GR non-small cell lung cancer (NSCLC).

A comparison of four different models of acute respiratory distress syndrome in sheep

سبت, 08/08/2020 - 02:00
Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and...

Functional glutamate transporters are expressed in the carotid chemoreceptor

سبت, 08/08/2020 - 02:00
The carotid body (CB) plays a critical role in cyclic intermittent hypoxia (CIH)-induced chemosensitivity; however, the underlying mechanism remains uncertain. We have demonstrated the presence of multiple ino...

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD

جمعة, 07/08/2020 - 02:00
The hedgehog (HH) pathway has been associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies and recent studies suggest that HH signalling could be altered in COPD. We the...

Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis

أربعاء, 05/08/2020 - 02:00
The importance of lipid mediators in allergic diseases has been long recognized, whereas little is known about their role in allergic bronchopulmonary aspergillosis (ABPA). We investigated whether lipid mediat...

Pregnancy-associated plasma protein A – a new indicator of pulmonary vascular remodeling in chronic thromboembolic pulmonary hypertension?

اثنين, 03/08/2020 - 02:00
In chronic thromboembolic pulmonary hypertension (CTEPH) impaired pulmonary hemodynamics lead to right heart failure. Natriuretic peptides reflect hemodynamic disease severity. Pregnancy-associated plasma prot...

Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort

اثنين, 03/08/2020 - 02:00
Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency roo...

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort

خميس, 30/07/2020 - 02:00
Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI c...

Association between cytokine profiles and lung injury in COVID-19 pneumonia

أربعاء, 29/07/2020 - 02:00
Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investiga...

Cell-specific expression of lung disease risk-related genes in the human small airway epithelium

أربعاء, 29/07/2020 - 02:00
The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specifi...

Tiotropium in chronic obstructive pulmonary disease – a review of clinical development

أربعاء, 29/07/2020 - 02:00
Bronchodilators are the mainstay of pharmacological treatment in chronic obstructive pulmonary disease (COPD), and long-acting muscarinic antagonist (LAMA) monotherapy is recommended as initial treatment for G...

The pathophysiology of ‘happy’ hypoxemia in COVID-19

ثلاثاء, 28/07/2020 - 02:00
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet wi...

The need for a holistic approach for SSc-ILD – achievements and ambiguity in a devastating disease

خميس, 23/07/2020 - 02:00
Systemic sclerosis (SSc) is a multi-organ autoimmune disease with complex interactions between immune-mediated inflammatory processes and vascular pathology leading to small vessel obliteration, promoting unco...

Patient expectations, experiences and satisfaction with nintedanib and pirfenidone in idiopathic pulmonary fibrosis: a quantitative study

خميس, 23/07/2020 - 02:00
Two antifibrotic drugs, nintedanib and pirfenidone, are available for treatment of idiopathic pulmonary fibrosis (IPF). Although efficacy and adverse events have been well studied, little is known about patien...

Palliation of chronic breathlessness with morphine in patients with fibrotic interstitial lung disease – a randomised placebo-controlled trial

خميس, 23/07/2020 - 02:00
Patients suffering from fibrotic interstitial lung diseases (fILD) have a poor prognosis and a high symptom burden. Palliative treatment includes relief of symptoms such as breathlessness. There is no evidence...

Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19

أربعاء, 22/07/2020 - 02:00
Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.

LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice

ثلاثاء, 21/07/2020 - 02:00
RSV can lead to persistent airway inflammation and airway hyperresponsiveness (AHR), and is intimately associated with childhood recurrent wheezing and asthma, but the underlying mechanisms remain unclear. Lip...

Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality

اثنين, 20/07/2020 - 02:00
Severity of community-acquired pneumonia (CAP) depends on microbial pathogenicity, load and virulence, and immune responses. The Infectious Disease Society of America and the American Thoracic Society (IDSA/AT...

Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea

سبت, 18/07/2020 - 02:00
Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one ...