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Most Recent Articles: Respiratory Research
آخر تحديث: منذ ساعة واحدة 29 دقيقة

Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission

خميس, 21/01/2021 - 01:00
Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is rel...

Risk assessment in precapillary pulmonary hypertension: a comparative analysis

خميس, 21/01/2021 - 01:00
Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...

Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study

خميس, 21/01/2021 - 01:00
Although pulmonary vascular bed has been the main subject of research for many years in pulmonary hypertension (PH), interest has recently started to divert towards the possibility of a co-existing peripheral ...

Potential interactions between the TBX4-FGF10 and SHH-FOXF1 signaling during human lung development revealed using ChIP-seq

خميس, 21/01/2021 - 01:00
The epithelial-mesenchymal signaling involving SHH-FOXF1, TBX4-FGF10, and TBX2 pathways is an essential transcriptional network operating during early lung organogenesis. However, precise regulatory interactio...

Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

خميس, 21/01/2021 - 01:00
Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in ord...

Gene expression pattern analysis using dual-color RT-MLPA and integrative genome-wide association studies of eQTL for tuberculosis suscepitibility

أربعاء, 20/01/2021 - 01:00
When infected with Mycobacterium tuberculosis, only a small proportion of the population will develop active TB, and the role of host genetic factors in different TB infection status was not fully understood.

Resveratrol attenuates cigarette smoke induced endothelial apoptosis by activating Notch1 signaling mediated autophagy

ثلاثاء, 19/01/2021 - 01:00
Increasing evidence shows that endothelial apoptosis contributes to cigarette smoke (CS)-induced disease progression, such as chronic obstructive pulmonary disease (COPD). Our previous studies have validated N...

Correction to: A super-spreader of SARS-CoV-2 in incubation period among health-care workers

ثلاثاء, 19/01/2021 - 01:00
An amendment to this paper has been published and can be accessed via the original article.

Surfactant therapy for COVID-19 related ARDS: a retrospective case–control pilot study

اثنين, 18/01/2021 - 01:00
COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVI...

Dietary phenotype and advanced glycation end-products predict WTC-obstructive airways disease: a longitudinal observational study

اثنين, 18/01/2021 - 01:00
Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, ...

The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD

جمعة, 15/01/2021 - 01:00
Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship be...

Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study

جمعة, 15/01/2021 - 01:00
For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the re...

More skilled clinical management of COVID-19 patients modified mortality in an intermediate respiratory intensive care unit in Italy

جمعة, 15/01/2021 - 01:00
Some studies investigated epidemiological and clinical features of laboratory-confirmed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus causing coronavirus disease 2019 (CO...

Asthma in elderly is characterized by increased sputum neutrophils, lower airway caliber variability and air trapping

أربعاء, 13/01/2021 - 01:00
Elderly asthmatics represent an important group that is often excluded from clinical studies. In this study we wanted to present characteristics of asthmatics older than 70 years old as compared to younger pat...

The elastin peptide VGVAPG increases CD4+ T-cell IL-4 production in patients with chronic obstructive pulmonary disease

أربعاء, 13/01/2021 - 01:00
In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, ...

Ruling out COVID-19 by chest CT at emergency admission when prevalence is low: the prospective, observational SCOUT study

ثلاثاء, 12/01/2021 - 01:00
It is essential to avoid admission of patients with undetected corona virus disease 2019 (COVID-19) to hospitals’ general wards. Even repeated negative reverse transcription polymerase chain reaction (RT-PCR) ...

Conceptions of the pathophysiology of happy hypoxemia in COVID-19

جمعة, 08/01/2021 - 01:00
In their letter-to-the-editor entitled “Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19”, Tobin et al. (Respir Res 21:249, 2020) debated our views on happy hypo...

Antibiotic treatment in acute exacerbation of COPD: patient outcomes with amoxicillin vs. amoxicillin/clavulanic acid—data from 43,636 outpatients

خميس, 07/01/2021 - 01:00
For antibiotic treatment of Acute exacerbations of COPD (AECOPD) the National guidelines in Denmark recommend either first choice amoxicillin 750 mg TID (AMX) or amoxicillin with clavulanic acid 500 mg/125 mg ...

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

خميس, 07/01/2021 - 01:00
Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are nee...