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Most Recent Articles: Respiratory Research
Updated: 1 hour 56 min ago

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

Wed, 07/01/2020 - 02:00
Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil...

Transcriptomic profiling reveals disease-specific characteristics of epithelial cells in idiopathic pulmonary fibrosis

Tue, 06/30/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) is an incurable disease characterized by progressive lung fibrosis ultimately resulting in respiratory failure and death. Recurrent micro-injuries to the alveolar epithelium...

Acute exacerbations of COPD versus IPF in patients with combined pulmonary fibrosis and emphysema

Tue, 06/30/2020 - 02:00
Patients with combined pulmonary fibrosis and emphysema (CPFE) may develop acute exacerbations of IPF (AE-IPF) or COPD (AE-COPD). The incidence and the characteristics of exacerbations in patients with CPFE (e...

Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase

Mon, 06/29/2020 - 02:00
This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease

Fri, 06/26/2020 - 02:00
Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individual...

Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production

Fri, 06/26/2020 - 02:00
Cigarette smoke (CS) is a major risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Epithelial-mesenchymal transition (EMT) commonly coexists in lung cancer and COP...

Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses

Tue, 06/23/2020 - 02:00
Neutrophil is of the most abundant number in human immune system. During acute influenza virus infection, neutrophils are already active in the early phase of inflammation - a time in which clinical biopsy or ...

Adoption of a dedicated multidisciplinary team is associated with improved survival in acute pulmonary embolism

Mon, 06/22/2020 - 02:00
Acute pulmonary embolism remains a significant cause of mortality and morbidity worldwide. Benefit of recently developed multidisciplinary PE response teams (PERT) with higher utilization of advanced therapies...

Improving the evaluation of COPD exacerbation treatment effects by accounting for early treatment discontinuations: a post-hoc analysis of randomized clinical trials

Mon, 06/22/2020 - 02:00
Chronic obstructive pulmonary disease (COPD) clinical trials aimed at evaluating treatment effects on exacerbations often suffer from early discontinuations of randomized treatment. Treatment discontinuations ...

Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study

Mon, 06/22/2020 - 02:00
Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

Performance of brief ICF-sleep disorders and obesity core set in obstructive sleep apnea patients

Mon, 06/22/2020 - 02:00
Clinical questionnaires are mainly applied as screening tools for identification of the Obstructive sleep apnea (OSA) patients. Little attention has been paid to assess the body functions and health status of ...

T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles

Fri, 06/19/2020 - 02:00
Asthma is a common and heterogeneous disease that includes subgroups characterized by type 2 (T2) or type 17 (T17) immune responses for which there is a need to identify the underlying mechanisms and biomarker...

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation

Thu, 06/18/2020 - 02:00
Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

The impact of adjuvant surgical treatment of nontuberculous mycobacterial pulmonary disease on prognosis and outcome

Tue, 06/16/2020 - 02:00
Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic fa...

Trends and seasonal variation of hospitalization and mortality of interstitial lung disease in the United States from 2006 to 2016

Tue, 06/16/2020 - 02:00
In the recent years, the overall trends in hospital admission and mortality of interstitial lung disease (ILD) are unknown. In addition, there was some evidence that interstitial lung disease death rate highes...

Interaction between obstructive sleep apnea and short sleep duration on insulin resistance: a large-scale study

Tue, 06/16/2020 - 02:00
Both short sleep duration and obstructive sleep apnea (OSA) seem to be associated with insulin resistance. We aimed to explore whether short sleep duration modifies the relationship between OSA and insulin res...

High flow nasal therapy during early pulmonary rehabilitation in patients with acute severe exacerbation of COPD: beneficial or illusory?

Fri, 06/12/2020 - 02:00
In study “Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study” by Tung et al., authors concluded HFNT utilization led to enhanced ...

CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial

Fri, 06/12/2020 - 02:00
Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung in preclinical and human models of neutrophilic airway inflammation. A previous stud...

A phase IIb, randomised, parallel-group study: the efficacy, safety and tolerability of once-daily umeclidinium in patients with asthma receiving inhaled corticosteroids

Fri, 06/12/2020 - 02:00
Patients with asthma uncontrolled on inhaled corticosteroids may benefit from umeclidinium (UMEC), a long-acting muscarinic antagonist.

Weighted Epworth sleepiness scale predicted the apnea-hypopnea index better

Fri, 06/12/2020 - 02:00
The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight i...

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