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Most Recent Articles: Respiratory Research
Updated: 1 hour 56 min ago

Effects of prostaglandin E1 nebulization of ventilated lung under 60%O2 one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial

Wed, 05/13/2020 - 02:00
High FiO2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E1 (PGE1) can improve oxy...

Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics

Tue, 05/12/2020 - 02:00
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number o...

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

Mon, 05/11/2020 - 02:00
The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective i...

FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients

Fri, 05/08/2020 - 02:00
The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

Thu, 05/07/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

Circulating microRNAs correlate to clinical parameters in individuals with allergic and non-allergic asthma

Thu, 05/07/2020 - 02:00
Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients – a retrospective analysis

Wed, 05/06/2020 - 02:00
In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...

Differences in airway microbiome and metabolome of single lung transplant recipients

Wed, 05/06/2020 - 02:00
Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

Validation of a method to assess emphysema severity by spirometry in the COPDGene study

Fri, 05/01/2020 - 02:00
Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells

Fri, 05/01/2020 - 02:00
In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

Heme metabolism genes Downregulated in COPD Cachexia

Fri, 05/01/2020 - 02:00
Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine

Thu, 04/30/2020 - 02:00
There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

IL-33, diet-induced obesity, and pulmonary responses to ozone

Thu, 04/23/2020 - 02:00
Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Wed, 04/22/2020 - 02:00
Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor pro...

The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China

Wed, 04/22/2020 - 02:00
The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease pr...

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Wed, 04/22/2020 - 02:00
It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and ...

Validation of age, PaO2/FlO2 and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study

Wed, 04/22/2020 - 02:00
A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO2/FlO2, and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasi...

Impact of baseline symptoms and health status on COPD exacerbations in the FLAME study

Wed, 04/22/2020 - 02:00
COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.