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Most Recent Articles: Respiratory Research
Updated: 1 hour 31 min ago

The pulmonary sequalae in discharged patients with COVID-19: a short-term observational study

Sun, 05/24/2020 - 02:00
A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at e...

Automatization and improvement of μCT analysis for murine lung disease models using a deep learning approach

Sun, 05/24/2020 - 02:00
One of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated th...

IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters

Sun, 05/24/2020 - 02:00
Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respirat...

Correction to: The ‘can do, do do’ concept in COPD; quadrant interpretation, affiliation and tracking longitudinal changes

Sat, 05/23/2020 - 02:00
An amendment to this paper has been published and can be accessed via the original article.

Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner

Wed, 05/20/2020 - 02:00
The predominant metastatic site of lung cancer (LC) is the brain. Although outdated, conventional cisplatin treatment is still the main therapeutic approach for patients with advanced non-small cell lung cance...

Longitudinal functional changes with clinically significant radiographic progression in idiopathic pulmonary fibrosis: are we following the right parameters?

Tue, 05/19/2020 - 02:00
Progression of the disease in idiopathic pulmonary fibrosis (IPF) is difficult to predict, due to its variable and heterogenous course. The relationship between radiographic progression and functional decline ...

Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study

Tue, 05/19/2020 - 02:00
Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive statins. ...

Targeted lung denervation in sheep: durability of denervation and long-term histologic effects on bronchial wall and peribronchial structures

Mon, 05/18/2020 - 02:00
Targeted lung denervation (TLD), a novel bronchoscopic procedure which attenuates pulmonary nerve input to the lung to reduce the clinical consequences of neural hyperactivity, may be an important emerging tre...

MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome

Mon, 05/18/2020 - 02:00
Neutrophilic subtype asthma occurs in approximately 15–25% of the asthma cases and is associated with severe airflow obstruction, corticosteroid resistance. MicroRNA plays a vital role in regulating many immun...

Role of rhinomanometry in the prediction of therapeutic positive airway pressure for obstructive sleep apnea

Wed, 05/13/2020 - 02:00
This study was conducted to evaluate the relationship between nasal resistance in different posture and optimal positive airway pressure (PAP) level. Other potential factors were also assessed for possible inf...

Effects of prostaglandin E1 nebulization of ventilated lung under 60%O2 one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial

Wed, 05/13/2020 - 02:00
High FiO2 during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E1 (PGE1) can improve oxy...

Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics

Tue, 05/12/2020 - 02:00
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number o...

Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

Mon, 05/11/2020 - 02:00
The pulmonary diseases are one of the most important causes of death in the world. The successful therapies in the field of lung diseases are very limited and the medical treatments available are ineffective i...

FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients

Fri, 05/08/2020 - 02:00
The pneumonia severity index (PSI) and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥ 65 years) score have been shown to predict mortality in community-acquired pneumonia. Their ability ...

Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

Thu, 05/07/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic comp...

Circulating microRNAs correlate to clinical parameters in individuals with allergic and non-allergic asthma

Thu, 05/07/2020 - 02:00
Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medi...

High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients – a retrospective analysis

Wed, 05/06/2020 - 02:00
In COPD, the course of the disease including morbidity and mortality is strongly associated with severe exacerbations. The current GOLD recommendations emphasize blood eosinophil counts as a marker for respons...