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Most Recent Articles: Respiratory Research
Updated: 1 hour 23 min ago

Differences in airway microbiome and metabolome of single lung transplant recipients

Wed, 05/06/2020 - 02:00
Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized th...

Validation of a method to assess emphysema severity by spirometry in the COPDGene study

Fri, 05/01/2020 - 02:00
Standard spirometry cannot identify the predominant mechanism underlying airflow obstruction in COPD, namely emphysema or airway disease. We aimed at validating a previously developed methodology to detect emp...

Extracellular vesicles from mast cells induce mesenchymal transition in airway epithelial cells

Fri, 05/01/2020 - 02:00
In the airways, mast cells are present in close vicinity to epithelial cells, and they can interact with each other via multiple factors, including extracellular vesicles (EVs). Mast cell-derived EVs have a la...

Heme metabolism genes Downregulated in COPD Cachexia

Fri, 05/01/2020 - 02:00
Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...

Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine

Thu, 04/30/2020 - 02:00
There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS and could serve as potential targets for developing th...

IL-33, diet-induced obesity, and pulmonary responses to ozone

Thu, 04/23/2020 - 02:00
Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesi...

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Wed, 04/22/2020 - 02:00
Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor pro...

The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China

Wed, 04/22/2020 - 02:00
The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease pr...

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Wed, 04/22/2020 - 02:00
It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and ...

Validation of age, PaO2/FlO2 and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study

Wed, 04/22/2020 - 02:00
A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO2/FlO2, and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasi...

Impact of baseline symptoms and health status on COPD exacerbations in the FLAME study

Wed, 04/22/2020 - 02:00
COPD is a heterogeneous disease and patients may respond differently to therapies depending on baseline symptom burden.

Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis

Tue, 04/21/2020 - 02:00
Idiopathic pulmonary fibrosis (IPF) specific version of St. George’s Respiratory Questionnaire (SGRQ-I) and King’s Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of...

Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease

Mon, 04/20/2020 - 02:00
Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obs...

Different expression levels of interleukin-35 in asthma phenotypes

Thu, 04/16/2020 - 02:00
Interleukin (IL)-35 is a newly discovered inhibitory cytokine which is produced by regulatory B and T lymphocytes and belongs to the IL-12 family. It plays a suppressive role in human inflammatory diseases; ho...

Letter to the editor: indacaterol/glycopyrronium/mometasone furoate compared with salmeterol/fluticasone propionate in patients with asthma: a randomized controlled cross-over study

Wed, 04/15/2020 - 02:00
Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatme...

Factors associated with intraoperative extracorporeal membrane oxygenation support during lung transplantation

Wed, 04/15/2020 - 02:00
Intraoperative Extracorporeal membrane oxygenation (ECMO) is increasingly being applied as life-support for lung transplantation patients. However, factors associated with this procedure in lung transplantatio...

Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study

Wed, 04/15/2020 - 02:00
Chronic obstructive pulmonary disease (COPD) is airway inflammation characterized and low daily physical activity. Most pulmonary rehabilitation (PR) programs are often provided to stable patients, but fewer t...

Prognostic value of NT-proBNP in patients with severe COVID-19

Wed, 04/15/2020 - 02:00
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The car...

Lung volume dependence of respiratory function in rodent models of diabetes mellitus

Thu, 04/09/2020 - 02:00
Diabetes mellitus causes the deterioration of smooth muscle cells and interstitial matrix proteins, including collagen. Collagen and smooth muscle cells are abundant in the lungs, but the effect of diabetes on...